Description

Registry Version: 3.0

This website is designed for research purposes only. The contents are not intended for making clinical decisions regarding donor selection or patient care.

There are six separate databases: ABC, DRB1/3/4/5, DQB + DQA, DPB + DPA, Interlocus Cl. II and MICA.

Their layouts display:

  • 1 Eplet name.
  • 2 ElliPro - score derived from the ElliPro Antibody Epitope Prediction tool for determining eplet immunogenicity.
  • 3 Polymorphic residues - the amino acid positions and specific residues that describe the eplet.
  • 4 Frequency - link to the Allele Frequency Net Database website for eplet frequencies in different populations.
  • 5 Antibody reactivity - link to antibody reactivity reports for antibody-verified eplets and information for any eplet pairs, i.e, eplet variants in combination with distinct amino acid configurations shared by reactive alleles.
  • 6 Struct epitope - link to more information about the corresponding “structural” epitope, a set of amino acid residues within a 15 Ångstrom radius, that may help to explain antibodies that react only with a subgroup of epitope-carrying alleles (because they require the eplet to be paired with other residue configurations).
  • 7 Luminex alleles - list of alleles, commonly used in Luminex panels, that share the eplet.
  • 8 All alleles - list of all alleles that share the eplet.

Each eplet has its own row, and eplets are sorted according to their amino acid sequence positions. Each database has search options to identify repertoires of antibody-verified eplets on selected alleles and eplets that are mismatched for a given HLA type. A new feature is the “EpiPedia of HLA”, which summarizes the experimental evidence for each antibody-verified HLA eplet. Click here to download the PDF. For more detailed information about the HLA Epitope Registry, click here.

New Eplets

This Registry is a work-in-progress and we plan to have quarterly updates that incorporate new antibody-verified eplets and additional information about antibody reactivity.

HLA professionals are encouraged to Contact Us to submit antibody reactivity data for new HLA eplets and other relevant information. Contributions will be acknowledged in the Registry.

Contact us for additional information on the eplet databases or the website.